At14-3-3 inhibitor 2

Chemical Structure : At14-3-3 inhibitor 2

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货号: PC-22228Not For Human Use, Lab Use Only.

At14-3-3 inhibitor 2 is a covalent selective inhibitor for Arabidopsis thaliana 14-3-3 protein (At14-3-3), potently inhibits the interaction between At14-3-3 Lambda and FAM-FD with IC50 of 1.2 uM.

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250 mg		Get quote

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生物&药学活性

At14-3-3 inhibitor 2 is a covalent selective inhibitor for Arabidopsis thaliana 14-3-3 protein (At14-3-3), potently inhibits the interaction between At14-3-3 Lambda and FAM-FD with IC50 of 1.2 uM.
At14-3-3 inhibitor 2 covalently binds to an allosteric site of 14-3-3 (Cys198) with isoform selectivity.
Infiltration of At14-3-3 inhibitor 2 to Arabidopsis leaves suppressed the stomatal aperture.

物理化学性质&存储条件

分子量	441.45
分子式	C22H19NO7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(indolin-1-yl)-2-oxoethyl 1,4-dihydroxy-3-(methylsulfonyl)-2-naphthoate

参考文献

1. Kotaro Nishiyama, et al. Angew Chem Int Ed Engl. 2024 Apr 24:e202400218.