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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Asunaprevir
Asunaprevir

Chemical Structure : Asunaprevir

CAS No.: 630420-16-5

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Asunaprevir (BMS-650032, BMS650032)

货号: PC-25230Not For Human Use, Lab Use Only.

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor with IC50 of 0.2-3.5 nM, also inhibits SARS-CoV-2 3CLpro activity.

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10 mg ￥1480 In stock
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50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Asunaprevir (BMS-650032) is a potent and orally bioavailable HCV NS3 protease inhibitor with IC50 of 0.2-3.5 nM, also inhibits SARS-CoV-2 3CLpro activity.

物理化学性质&存储条件

分子量 748.29
分子式 C35H46ClN5O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-Butyl ((S)-1-((2S,4R)-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

参考文献

1. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Jul 30.

2. McPhee F, et al. Antimicrob Agents Chemother. 2012 Aug 6.

3. Pasquinelli C, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):1838-44.

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