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首页-抗体药物偶连体和PROTACs-PROTAC-Aster-A PROTAC NGF3
Aster-A PROTAC NGF3

Chemical Structure : Aster-A PROTAC NGF3

CAS No.: 3038774-43-2

Aster-A PROTAC NGF3

货号: PC-24732Not For Human Use, Lab Use Only.

Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells.

物理化学性质&存储条件

分子量 845.97
分子式 C42H51N7O10S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

tert-butyl 2-(4-((3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamoyl)benzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

参考文献

1. He N, et al. Bioorg Med Chem. 2024 Apr 1;103:117673.

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