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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-Amdizalisib
Amdizalisib

Chemical Structure : Amdizalisib

CAS No.: 1894229-05-0

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Amdizalisib (HMPL-689, HMPL689)

货号: PC-38383Not For Human Use, Lab Use Only.

Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity.
    Amdizalisib (HMPL-689) is under clinical investigation for the treatment of relapsed or refractory follicular lymphoma (FL), a subtype of non-Hodgkin's lymphoma (NHL).

    物理化学性质&存储条件

    分子量 390.835
    分子式 C19H15ClN8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile

    参考文献

    1. Tunde Lawrence, et al. Cancer Res (2020) 80 (16_Supplement): 5234.

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