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首页-抗体和重组蛋白-Biosimilar Antibody-Amatuximab
Amatuximab

Chemical Structure : Amatuximab

CAS No.: 931402-35-6

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Amatuximab (Anti-human MSLN mAb, human IgG1-Kappa; MORAb-009)

货号: PC-Ab1080Not For Human Use, Lab Use Only.

Mesothelin (MSLN) is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Amatuximab (MORAb-009) blocks the binding of mesothelin to CA 125 and thus could be used also as a strategy to prevent tumor metastasis..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mesothelin (MSLN) is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Amatuximab (MORAb-009) blocks the binding of mesothelin to CA 125 and thus could be used also as a strategy to prevent tumor metastasis.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Amatuximab; MORAb-009; MORAb009; 931402-35-6; anti human MSLN; anti human Mesothelin

参考文献

1. 1, Nicolaides NC, et al. Cancer Biol Ther. 2018 Jul 3;19(7):622-630. 2, Hassan R, et al. Cancer Immun. 2007 Dec 19;7:20. 3, Hassan R, et al. Clin Cancer Res. 2010 Dec 15;16(24):6132-8. 4, Shin IS, et al. Nucl Med Biol. 2011 Nov;38(8):1119-27.

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