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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -Agrimol B
Agrimol B

Chemical Structure : Agrimol B

CAS No.: 55576-66-4

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Agrimol B

货号: PC-28290Not For Human Use, Lab Use Only.

Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb., significantly induces cytoplasm-to-nucleus shuttle of SIRT1, inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression, blocks adipogenesis at the early stage of differentiation with IC50 of 3.35 uM.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb., significantly induces cytoplasm-to-nucleus shuttle of SIRT1, inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression, blocks adipogenesis at the early stage of differentiation with IC50 of 3.35 uM.
Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis.
Agrimol B downregulates the protein level of NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1) through caspase 3-mediated degradation, leading to mitochondrial reactive oxygen species (mROS) accumulation and autophagy arrest.
Agrimol B significantly enhances the sensitivity of HCC cells to sorafenib in vitro and in vivo.
Agrimol B inhibits the growth and proliferation of HCC cells in vitro as well as in an HCC patient-derived xenograft (PDX) model.

物理化学性质&存储条件

分子量 682.76
分子式 C37H46O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)

参考文献

1. Wang S, et al. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.

2. Hnit SST, et al. Biomed Pharmacother. 2021 Sep;141:111795.

3. Dong L, et al. Free Radic Biol Med. 2024 Aug 1;220:111-124.

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