Adamastat

Chemical Structure : Adamastat

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货号: PC-27371Not For Human Use, Lab Use Only.

Adamastat is a specific small molecule ADAM15 inhibitor, triggers the reduction of bladder cancer cell viability.

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生物&药学活性

Adamastat is a specific small molecule ADAM15 inhibitor, triggers the reduction of bladder cancer cell viability.
Adamastat binds to the active site of the ADAM15 metalloproteinase domain with a calculated binding energy of -9.0 kcal/mol.
Adamastat significantly inhibits the viability of UM-UC-9 and UM-UC-6 cells at 10 uM.
Adamastat (100 mg/kg) reduced tumor growth by 83.8% in grafted UM-UC-6 cells subcutaneously in SCID mice.

物理化学性质&存储条件

分子量	435.50
分子式	C23H21N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4'-amino-[1,1'-biphenyl]-4-yl)sulfonyl)-D-tryptophan

参考文献

1. Lorenzatti Hiles G, et al. PLoS One. 2016 Mar 1;11(3):e0150138.

Adamastat

生物&药学活性

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Adamastat

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