Acmiribine | Rac1 inhibitor | Probechem Biochemicals

Chemical Structure : Acmiribine

CAS No.: 88847-89-6

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Acmiribine (8-hydroxy-2'-deoxyguanosine, 8-OHdG)

货号: PC-27402Not For Human Use, Lab Use Only.

Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) is a small molecule Rac1 inhibitor, suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) is a small molecule Rac1 inhibitor, suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.
Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) significantly reduces plaque formation along with reduced superoxide formation, monocyte/macrophage infiltration, and extracellular matrix (ECM) accumulation in mice.
Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) significantly inhibits angiotensin II-induced Rac1 activity in VSMCs.
Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1.
Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) suppresses allergy-induced lung tissue remodeling in mice, inhibits allergy-induced inflammation and remodeling in airway and lung tissues through Rac inactivation.
Acmiribine (8-Hydroxy-2-deoxyguanosine, 8-OHdG) could prevent liver fibrosis by inhibiting Rac1-NADPH oxidase 2 (NOX2) signaling in this MASH model.

物理化学性质&存储条件

分子量	283.24
分子式	C10H13N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione

参考文献

1. Pan Y, et al. Exp Neurol. 2018 Feb;300:149-166.

2. Huh JY, et al. Biochem Biophys Res Commun. 2017 Sep 30;491(4):890-896.

3. Kim HS, et al. Free Radic Biol Med. 2006 Nov 1;41(9):1392-403.

4. Kim JS, et al. Eur J Pharmacol. 2011 Jan 25;651(1-3):218-26.

Acmiribine (8-hydroxy-2'-deoxyguanosine, 8-OHdG)

生物&药学活性

物理化学性质&存储条件

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Acmiribine (8-hydroxy-2'-deoxyguanosine, 8-OHdG)

生物&药学活性

物理化学性质&存储条件

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