Acid ceramidase inhibitor 43

Chemical Structure : Acid ceramidase inhibitor 43

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货号: PC-25384Not For Human Use, Lab Use Only.

Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell).
Acid ceramidase inhibitor 43 promotes human hepatic stellate cells (HSCs) inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2.
Acid ceramidase inhibitor 43 significantly inhibited YAP/TAZ nuclear localization in HSCs.

物理化学性质&存储条件

分子量	443.52
分子式	C27H26FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((4-fluorobenzyl)oxy)phenyl)-N-(4-phenylbutyl)-1H-imidazole-1-carboxamide

参考文献

1. Beresis R, et al. ACS Omega. 2025 Jul 31;10(31):34747-34761.