Acevaltrate

Chemical Structure : Acevaltrate

CAS No.: 25161-41-5

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货号: PC-24932Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
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100 mg		Get quote

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生物&药学活性

Acevaltrate is a novel ferroptosis inducer and dual inhibitor of PCBP1/2 and GPX4, also inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively.
Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1alpha accumulation in cancer cells.
Acevaltrate not only increases Fe2+ levels in colorectal cancer cells by targeting iron chaperones PCBP1/2 and reducing their expression but also disrupts the antioxidant system of colorectal cancer cells by targeting GPX4 and inhibiting its enzymatic activity, leading to its ubiquitin-mediated degradation.
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria.

物理化学性质&存储条件

分子量	480.51
分子式	C24H32O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,6S,7R,7aS)-4-(Acetoxymethyl)-1-((3-methylbutanoyl)oxy)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-6-yl 3-acetoxy-3-methylbutanoate

参考文献

1. Bettero GM, et al. Planta Med. 2011 Oct;77(15):1702-6.

2. Wang Y, et al. Eur J Pharmacol. 2025 Jun 5;996:177572.

3. Yu D, et al. Signal Transduct Target Ther. 2025 Jul 7;10(1):211.

Acevaltrate

生物&药学活性

物理化学性质&存储条件

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Acevaltrate

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