Acebilustat (CTX-4430, EP-501)

Chemical Structure : Acebilustat

CAS No.: 943764-99-6

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货号: PC-45393Not For Human Use, Lab Use Only.

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.
Acebilustat (CTX-4430, EP-501) a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.

物理化学性质&存储条件

分子量	481.5424
分子式	C29H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO; Methanol: ≥ 32 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-

参考文献

1. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):20-27.

2. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):28-34.