Ac5GlutolNAc

Chemical Structure : Ac5GlutolNAc

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货号: PC-25267Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Ac5GlutolNAc is a specific small molecule inhibitor of GlcNAc 2-epimerase (RENBP), selectively enhances the labeling efficiency of tetraacetyl-N-azidoacetylmannosamine (AAM) in antigen-presenting cells (APCs), but not non-APCs.
Ac5GlutolNAc (200-400 μM) significantly enhances AAM labeling efficiency without compromising the viability of DC2.4 cells.
Ac5GlutolNAc inhibits the flux from ManNAc toward GlcNAc and facilitates subsequent sialic acid biosynthesis.
Ac5GlutolNAc specifically amplifies AAM labeling efficiency in primary dendritic cells.
Ac5GlutolNAc interferes with the sialic acid synthetic pathways but not the GalNAc glycan synthesis pathways.
Ac5GlutolNAc amplifies AAM-mediated metabolic labeling of B cells and other immune cells in vivo.
Ac5GlutolNAc can enhance the labeling efficiency of AAM toward various types of APCs (dendritic cells, macrophages, and B cells).

物理化学性质&存储条件

分子量	433.41
分子式	C18H27NO11:
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R,5S)-5-acetamidohexane-1,2,3,4,6-pentayl pentaacetate

参考文献

1. Liu Y, et al. Cell Chem Biol. 2025 Aug 4:S2451-9456(25)00224-7.

Ac5GlutolNAc

生物&药学活性

物理化学性质&存储条件

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Ac5GlutolNAc

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物理化学性质&存储条件

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