AZD9750 (AZD-9750)

Chemical Structure : AZD9750

CAS No.: 3056515-10-4

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货号: PC-28726Not For Human Use, Lab Use Only.

AZD9750 is a potent, selective and orally bioavailable Androgen Receptor (AR) PROTAC degrader with DC50 of 10 nM and 12 nM for AR WT and AR L702H respectively. showed extensive degradation of AR, including L702H AR (Dmax >100%).

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1 mg	￥2180	In stock
5 mg	￥4980	In stock
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25 mg		Get quote

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生物&药学活性

AZD9750 is a potent, selective and orally bioavailable Androgen Receptor (AR) PROTAC degrader with DC50 of 10 nM and 12 nM for AR WT and AR L702H respectively. showed extensive degradation of AR, including L702H AR (Dmax >100%).
AZD9750 inhibits tumor growth in vivo in a mouse prostate cancer xenograft model.

物理化学性质&存储条件

分子量	758.37
分子式	C43H48ClN9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-Chloro-7-(3-(4-(4-((4-(6-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indol-2-yl)piperidin-1-yl)methyl)piperidin-1-yl)phenyl)piperidin-1-yl)-1H-indazole-3-carbonitrile

参考文献

1. Scott JS, et al. J Med Chem. 2026 Feb 12;69(3):3209-3232.

AZD9750 (AZD-9750)

生物&药学活性

物理化学性质&存储条件

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AZD9750 (AZD-9750)

生物&药学活性

物理化学性质&存储条件

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