Londamocitinib (AZD4604) | JAK1 inhibitor | Probechem Biochemicals

Chemical Structure : AZD4604

CAS No.: 2241039-81-4

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AZD4604 (Londamocitinib, AZD-4604)

货号: PC-72603Not For Human Use, Lab Use Only.

AZD4604 (Londamocitinib, AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members.

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2 mg	￥2180	In stock
5 mg	￥3580	In stock
10 mg	￥5480	In stock
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生物&药学活性

AZD4604 (Londamocitinib, AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members.

AZD4604 effectively inhibits the differentiation of Th1, Th2, and Th17 cells as indicated by a dose-dependent decrease in the production of Th-specific signature cytokines including reduction in IL-4, IL-5, and IL-13 productions by Th2 cells.

AZD4604 significantly blocks IL-4-induced STAT6 phosphorylation in CD4+ T cells.
AZD4604 blocks IL-13-induced STAT6 phosphorylation in monocytes with IC50 of 28 nM.
AZD4604 shows anti-inflammatory effect.

物理化学性质&存储条件

分子量	599.658
分子式	C28H31F2N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-(5-fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide

参考文献

1. Magnus Nilsson, et al. J Med Chem. 2023 Sep 22. doi: 10.1021/acs.jmedchem.3c00554.

AZD4604 (Londamocitinib, AZD-4604)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD4604 (Londamocitinib, AZD-4604)

生物&药学活性

物理化学性质&存储条件

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