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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-AZD4144
AZD4144

Chemical Structure : AZD4144

CAS No.: 2890191-41-8

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AZD4144 (AZD-4144)

货号: PC-23831Not For Human Use, Lab Use Only.

AZD4144 is a potent, direct and selective NLPR3 inflammasome inhibitor with IC50 of 76 nM (inhibition of nigericin-triggered speck formation), inhibits LPS/ATP-induced IL-1β and IL-18 release in mouse with IC50 of 54 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD4144 is a potent, direct and selective NLPR3 inflammasome inhibitor with IC50 of 76 nM (inhibition of nigericin-triggered speck formation), inhibits LPS/ATP-induced IL-1β and IL-18 release in mouse with IC50 of 54 nM.
AZD4144 binds directly to NLRP3 and competes with MCC950 for binding to the protein.
AZD4144 has beneficial pharmacokinetic properties, and shows a favorable off-target pharmacology profile.

物理化学性质&存储条件

分子量 379.34
分子式 C18H16F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,2-Propanediol, 3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]-1-phthalazinyl]amino]-, (2S)-

参考文献

1. Patent WO2024141534 A1.
2. Johansson A, et al. J Med Chem. 2025 Jul 9. doi: 10.1021/acs.jmedchem.5c00781.

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