AZD3988 | DGAT-1 inhibitor | Probechem Biochemicals

Chemical Structure : AZD3988

CAS No.: 892489-52-0

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AZD3988 (AZD 3988, AZD-3988)

货号: PC-20385Not For Human Use, Lab Use Only.

AZD3988 (AZD-3988) is a potent, selective DGAT-1 inhibitor with IC50 of 0.6/0.5/1.1 nM for human/mouse/rat DGAT-1, does not inhibit DGAT-2 at 10 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZD3988 (AZD-3988) is a potent, selective DGAT-1 inhibitor with IC50 of 0.6/0.5/1.1 nM for human/mouse/rat DGAT-1, does not inhibit DGAT-2 at 10 uM.
AZD3988 potently inhibits triacylglycerol synthesis in HuTu 80 cells with IC50 of 0.5 nM, has IC50 of 0.3 nM in the rat adipose TAG synthesis assay.
AZD3988 (20 mg/kg, p.o. bid) reduced in diet-induced obesity (DIO) model.

物理化学性质&存储条件

分子量	456.45
分子式	C23H22F2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid

参考文献

1. McCoull W, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.

AZD3988 (AZD 3988, AZD-3988)

生物&药学活性

物理化学性质&存储条件

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AZD3988 (AZD 3988, AZD-3988)

生物&药学活性

物理化学性质&存储条件

参考文献

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