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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-AZD3147
AZD3147

Chemical Structure : AZD3147

CAS No.: 1101810-02-9

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AZD3147 (AZD-3147;AZD 3147)

货号: PC-60482Not For Human Use, Lab Use Only.

AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.
AZD3147 weakly inhibits PI3K isoforms with IC50 of 1-10 uM, potently inhibits pAKT at Ser473 with pIC50 of 8.25.
AZD3147 has exellentphysicochemical and pharmacokinetic properties.

 

物理化学性质&存储条件

分子量 517.7
分子式 C24H31N5O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea

参考文献

1. Pike KG, et al. J Med Chem. 2015 Mar 12;58(5):2326-49.

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