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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-AZD2716
AZD2716

Chemical Structure : AZD2716

CAS No.: 1845753-81-2

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AZD2716 (AZD-2716, AZD 2716)

货号: PC-60457Not For Human Use, Lab Use Only.

AZD2716 (AZD-2716) is a novel potent, selective, orally bioavailable sPLA2 inhibitor with excellent plasma sPLA2 inhibition (IC50=0.1 nM).

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10 mg ￥4580 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD2716 (AZD-2716) is a novel potent, selective, orally bioavailable sPLA2 inhibitor with excellent plasma sPLA2 inhibition (IC50=0.1 nM).
AZD2716 effectively inhibits sPLA2 activity (IC50 <14 nM) and suppresses production of sPLA2-IIa (IC50=176 nM), demonstrates significant activity (IC50=56 nM) in atherosclerotic plaque homogenates.
AZD2716 is a clinical candidate for the treatment of coronary artery disease.

物理化学性质&存储条件

分子量 373.452
分子式 C24H23NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-(5'-Benzyl-2'-carbamoylbiphenyl-3-yl)-2-methylpropanoic acid

参考文献

1. Giordanetto F, et al. ACS Med Chem Lett. 2016 Aug 9;7(10):884-889.

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