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首页-小分子抑制剂&激动剂-GPCR-Glucagon Receptor-AZD0186
AZD0186

Chemical Structure : AZD0186

CAS No.: 2922542-61-6

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AZD0186 (AZD-0186)

货号: PC-25613Not For Human Use, Lab Use Only.

AZD0186 is a potent, selective glucagon-like peptide-1 receptor (GLP-1R) agonist, shows concentration-dependent potentiation of GSIS in EndoC-βH5 cells with EC50 of 0.6 nM, improves glucose control and reduces body weight.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AZD0186 is a potent, selective glucagon-like peptide-1 receptor (GLP-1R) agonist, shows concentration-dependent potentiation of GSIS in EndoC-βH5 cells with EC50 of 0.6 nM, improves glucose control and reduces body weight.

物理化学性质&存储条件

分子量 636.53
分子式 C32H31Cl2N5O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-2-(((1R,6R)-5-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)-2,5-diazabicyclo[4.2.0]octan-2-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid

参考文献

1. Weier Qi, et al. J Pharmacol Exp Ther. 2025 Aug 28;392(10):103683.

2. Patent WO2023057427.

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