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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ATM/ATR-AZD0156
AZD0156

Chemical Structure : AZD0156

CAS No.: 1821428-35-6

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AZD0156 (AZD-0156, AZD 0156)

货号: PC-42030Not For Human Use, Lab Use Only.

AZD0156 (AZD-0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD0156 (AZD-0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.
AZD0156 exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.

物理化学性质&存储条件

分子量 461.556
分子式 C26H31N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 6.2 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

参考文献

1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.

2. Morgado-Palacin I, et al. Sci Signal. 2016 Sep 13;9(445):ra91.

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