AZD0022 (AZD-0022) | KRAS G12D inhibitor | Probechem Biochemicals

Chemical Structure : AZD0022

CAS No.: 2958627-18-2

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AZD0022 (AZD-0022 )

货号: PC-24666Not For Human Use, Lab Use Only.

AZD0022 (AZD-0022) is a potent, selective, reversible and orally bioavailable inhibitor of KRAS G12D, shows high affinity to both the active (KRASG12D-GTP) and inactive forms of KRASG12D (KRASG12D-GDP) protein, and selectivity over wild-type KRAS, demonstrates broad anti-tumour activity across KRAS G12D-mutant tumour types.

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1 mg	￥2980	In stock
5 mg	￥7980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

AZD0022 (AZD-0022) is a potent, selective, reversible and orally bioavailable inhibitor of KRAS G12D, shows high affinity to both the active (KRASG12D-GTP) and inactive forms of KRASG12D (KRASG12D-GDP) protein, and selectivity over wild-type KRAS, demonstrates broad anti-tumour activity across KRAS G12D-mutant tumour types.

物理化学性质&存储条件

分子量	614.65
分子式	C34H30F4N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Naphthalenamine, 4-[4-(3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-6,8-difluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]-7-quinazolinyl]-5-ethynyl-6-fluoro-, (4R)-

参考文献

1. Kevin Beaumont, et al. Cancer Res (2025) 85 (8_Supplement_1): 841.

AZD0022 (AZD-0022 )

生物&药学活性

物理化学性质&存储条件

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AZD0022 (AZD-0022 )

生物&药学活性

物理化学性质&存储条件

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