AZ5385 | Rhinovirus inhibitor | Probechem Biochemicals

Chemical Structure : AZ5385

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AZ5385 (AZ 5385, AZ-5385)

货号: PC-21961Not For Human Use, Lab Use Only.

AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.

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生物&药学活性

AZ5385 is a small molecule EGFR inhibitor, also exhibits potent anti-HRV (human rhinovirus) activity with EC50 of 0.35 uM for HRV-2 in cell protection colorimetric assay, targeting the VP1 pocket of HRV.
AZ5385 is able to inhibit infection of cells by another HRV-A, i.e., HRV-16, and by RSV strain A2 but not by HRV-B type 14 (HRV-14), poliovirus type 1, SARS-2 coronavirus isolate DE-P3, and HSV-2 strain 333.
AZ5385 does not inhibit the pEGFR expression in cells but reduces the number of HRV-2-infected cells.
AZ5385 preferentially targets HRV progeny virions during their maturation in infected cells.

物理化学性质&存储条件

分子量	460.89
分子式	C22H22ClFN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-((4-((3-chloro-2-fluorophenyl)amino)-6-hydroxyquinazolin-7-yl)oxy)piperidin-1-yl)-2-hydroxypropan-1-one

参考文献

1. Masum Miah, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106423.

AZ5385 (AZ 5385, AZ-5385)

生物&药学活性

物理化学性质&存储条件

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AZ5385 (AZ 5385, AZ-5385)

生物&药学活性

物理化学性质&存储条件

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