AZ14289671 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : AZ14289671

加入收藏

AZ14289671 (AZ-14289671)

货号: PC-25435Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AZ14289671 is a potent, highly selective and blood-brain barrier penetrant irreversible inhibitor of EGFR exon 20 insertion (EGFRExon20Ins) mutations, inhibits EGFR phosphorylation across EGFRExon20Ins with IC50 of 17-41 nM, spares wild-type EGFR.
AZ14289671 is less potent with the mean IC50 ranging from 480 to 832 nM across EGFRWT cell lines.
AZ14289671 shows limited off-target inhibition activity against a panel of 400 kinases at 1 uM.
AZ14289671 is highly selective against EGFRExon20Ins with a high WT margin range between 10- and 50-fold depending on the pair of cell lines used.
AZ14289671 inhibits EGFR phosphorylation more extensively than sunvozertinib at lower doses in LXF2478ASV and clearly spares EGFRWT more effectively than sunvozertinib does in H2073WT.
AZ14289671 induced 133% TGI inhibition after 28 days of dosing at 50 mg/kg b.i.d. in LXF2478ASV xenografts.

物理化学性质&存储条件

分子量	499.30
分子式	C23H14Cl2F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(5-(2,5-dichloropyridin-3-yl)-2,4-difluorophenyl)-1-(pyrimidin-4-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)prop-2-en-1-one

参考文献

1. Swaih AM, et al. Cell Rep Med. 2025 Aug 20:102305.

AZ14289671 (AZ-14289671)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AZ14289671 (AZ-14289671)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.