AX-0085 | IFN-γ inhibitor, PD-L1 expression inhibitor

Chemical Structure : AX-0085

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AX-0085 (AX0085)

货号: PC-24461Not For Human Use, Lab Use Only.

AX-0085 is a specific PD-L1 expression inhibitor, blocks the IFN-γ-induced activation of JAK2/STAT1 pathway and up-regulation of PD-L1.

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AX-0085 is a specific PD-L1 expression inhibitor, blocks the IFN-γ-induced activation of JAK2/STAT1 pathway and up-regulation of PD-L1.
AX-0085 inhibits IFN-γ-induced PD-L1 expression.
AX-0085 effectively reduces IFN-γ-induced phosphorylation of JAK2 and STAT1.
AX-0085 reverses IFN-γ-induced inhibition of T cell activation.
AX-0085 enhances efficacy of anti-PD-1 antibody in vivo.
AX-0085 is highly specific in targeting the IFN-γ-pathway.
AX-0085 inhibits JAK2/STAT1 phosphorylation and STAT1 nuclear localization, thereby effectively blocking the IFN-γ-induced up-regulation of PD-L1 expression.
AX-0085 also is a small molecule AXL inhibitor, efficiently suppresses the AXL/GAS6 signaling pathway activation in TNBC cells in vitro.

物理化学性质&存储条件

分子量	553.93
分子式	C26H19ClF3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-chloro-5-(1-methyl-2-oxo-7-(phenylamino)-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)pyridin-3-yl)-3-(trifluoromethyl)benzamide

参考文献

1. Kim J, et al. Cells. 2021 Dec 22;11(1):19.

AX-0085 (AX0085)

生物&药学活性

物理化学性质&存储条件

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AX-0085 (AX0085)

生物&药学活性

物理化学性质&存储条件

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