Chemical Structure : AW-006
货号: PC-27863Not For Human Use, Lab Use Only.
AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro.
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AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro.
AW-006 interacts with SNX10 and reduces its thermal stability.
AW-006 abnormally enhances the SNX10 interacting within vesicular trafficking regulator Rab7 in living cells.
AW-006 shows anti-resorptive efficacy in ovariectomized mice, shows therapeutic potential in estrogen deficiency-induced bone loss.
| 分子量 | 282.81 | |
| 分子式 | C15H23ClN2O | |
| 外观性状 | Solid | |
| 储存条件 |
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| Solubility |
10 mM in DMSO |
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1. Li Y, et al. J Bone Miner Res. 2026 Aug 23:zjag126.
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