Chemical Structure : AVIL inhibitor Compound A
CAS No.:
1332084-64-6
AVIL inhibitor Compound A
(PLH1215, PLH-1215)
货号: PC-25980Not For Human Use, Lab Use Only.
AVIL inhibitor Compound A (PLH1215) is a specific small molecule actin-binding protein advillin (AVIL)-interacting compound with MST Kd of 6 uM, also blocks AVIL binding to its substrate actin.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
AVIL inhibitor Compound A (PLH1215) is a specific small molecule actin-binding protein advillin (AVIL)-interacting compound with MST Kd of 6 uM, also blocks AVIL binding to its substrate actin.
Compound A decreased the expression of FOXM1 and LIN28B in GBM cell lines U87 and A172, whereas abundance of AVIL itself was not affected, also also down-regulated at the RNA level of LIN28B.
Compound A killed U87 cell cultures at 10 μM, but TMZ was not effective even at 400 μM.
Compound A effectively kills four GBM cell lines-U87, A172, U251, and T98-at lower IC50 values (10 to 30 μM) than the astrocyte cell line (>120 μM).
Compound A induced a transcriptome profile similar to that of AVIL silencing by siRNA and caused down-regulation of FOXM1 and LIN28B, two known downstream targets of AVIL.
Compound A exhibited selectivity toward tumor cells, sparing astrocytes and neural stem cells in vitro.
Compound A impairs GBM and GBM stem cell growth and migration, extending survival in multiple mouse models of GBM, including TMZ-resistant models.
物理化学性质&存储条件
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分子量
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326.44
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分子式
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C19H26N4O
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1-(2-aminopyrimidin-4-yl)-3-(3-phenylpropyl)piperidin-3-yl)methanol
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参考文献
1. Xie Z, et al. Sci Transl Med. 2026 Jan 28;18(834):eadt1211.
