AV3-1 | TRPV3 activator | Probechem Biochemicals

Chemical Structure : AV3-1

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AV3-1 (TRPV3 activator 1)

货号: PC-25933Not For Human Use, Lab Use Only.

AV3-1 (TRPV3 activator 1) is a specific small molecule TRPV3 activator with EC50 of 2.0 μM for mouse TRPV3 and 7.2 μM for human TRPV3.

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生物&药学活性

AV3-1 (TRPV3 activator 1) is a specific small molecule TRPV3 activator with EC50 of 2.0 μM for mouse TRPV3 and 7.2 μM for human TRPV3.
TRPV3 activation via AV3-1 stimulates PI3 kinases in an EGFR-dependent manner.
AV3-1 activated mouse and human TRPV3 channels with higher potency than known TRPV3 activators in Ca2+ assays and electrophysiological recordings.
TRPV3 activator 1 stimulated ATP release in KU-19-19 bladder cancer cells.

物理化学性质&存储条件

分子量	408.50
分子式	C24H28N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-3a,6a(1H,4H)-dicarboxylate

参考文献

1. Zosel C, et al. Mol Pharmacol. 2025 Dec;107(12):100084.

2. Janenz J, et al. Mol Pharmacol. 2025 Nov 29;108(1):100096.

AV3-1 (TRPV3 activator 1)

生物&药学活性

物理化学性质&存储条件

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AV3-1 (TRPV3 activator 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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