AUT1 |CAS:1311136-84-1 Probechem Biochemicals

Chemical Structure : AUT1

CAS No.: 1311136-84-1

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AUT1 (AUT-1;AUT 1)

货号: PC-60647Not For Human Use, Lab Use Only.

AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively.
AUT1 displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters.
AUT1 increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM.
AUT1 rescues the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.

物理化学性质&存储条件

分子量	341.367
分子式	C18H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

参考文献

1. Rosato-Siri MD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.

2. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21.

3. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444.

AUT1 (AUT-1;AUT 1)

生物&药学活性

物理化学性质&存储条件

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AUT1 (AUT-1;AUT 1)

生物&药学活性

物理化学性质&存储条件

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