AUT00206 (AUT6)

Chemical Structure : AUT00206

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货号: PC-27688Not For Human Use, Lab Use Only.

AUT00206 (AUT6) is a specific positive allosteric modulator modulator of Kv3.1/3.2 potassium channels.

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生物&药学活性

AUT00206 (AUT6) is a specific positive allosteric modulator modulator of Kv3.1/3.2 potassium channels.
AUT00206 has no significant effect on dopamine (DA) synthesis capacity.
AUT00206 can enhance the activity of PV-positive interneurons to rescue gamma frequency cortical and hippocampal network synchrony in vitro.
AUT00206 shows little or no effect on other ion channels, receptors or enzymes.
AUT00206 selectively enhances the firing frequency of Kv3.1-expressing neurons and improves motor function and seizure susceptibility in Kcnc1-Arg320His/+ mice.

物理化学性质&存储条件

分子量	380.40
分子式	C20H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5-dimethyl-3-[2-(7-methylspiro[2H-benzofuran-3,1'cyclopropane]-4-yl)oxypyrimidin-5-yl]imidazolidine-2,4-dione

参考文献

1. Kaar SJ, et al. Psychopharmacology (Berl). 2022 Oct;239(10):3313-3323.

2. Feng H, et al. Cell Rep Med. 2024 Feb 20;5(2):101389.

3. Angelescu I, et al. J Psychopharmacol. 2022 Sep;36(9):1061-1069.

4. Stubbendorff C, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110829.

AUT00206 (AUT6)

生物&药学活性

物理化学性质&存储条件

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AUT00206 (AUT6)

生物&药学活性

物理化学性质&存储条件

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