AURKB PROTAC MS44

Chemical Structure : AURKB PROTAC MS44

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货号: PC-25153Not For Human Use, Lab Use Only.

AURKB PROTAC MS44 is a potent, selective, first-in-class Aurora B kinase (AURKB) PROTAC degrader with DC50 of 103 nM in HPAF-11 cells, Dmax of 89%.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AURKB PROTAC MS44 is a potent, selective, first-in-class Aurora B kinase (AURKB) PROTAC degrader with DC50 of 103 nM in HPAF-11 cells, Dmax of 89%.
MS44 induces AURKB degradation by hijacking the UPS.
MS44 selectively degrades AURKB over AURKA and AURKC.
MS44 effectively degrades AURKB and inhibits the proliferation in multiple cancer cell lines, induce G2/M arrest.

物理化学性质&存储条件

分子量	1090.33
分子式	C57H72FN11O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-((4-((5-(2-((3-Fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)-N10-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N1-(2-hydroxyethyl)decanediamide

参考文献

1. Xiaoping Hu, et al. Eur J Med Chem. 2025 Jul 24:298:118006.