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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-AU403
AU403

Chemical Structure : AU403

CAS No.:

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AU403 (AU-403)

货号: PC-27063Not For Human Use, Lab Use Only.

AU403 is a potent, isoform-selective LXRβ/PPARδ dual agonist with EC50 of 45/40 nM respectively, significantly improves cognitive functions and reduces amyloid-β plaque burden in 3xTg-AD animal model of Alzheimer's disease.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AU403 is a potent, isoform-selective LXRβ/PPARδ dual agonist with EC50 of 45/40 nM respectively, significantly improves cognitive functions and reduces amyloid-β plaque burden in 3xTg-AD animal model of Alzheimer's disease.

物理化学性质&存储条件

分子量 403.38
分子式 C22H17F4NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((((3-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)amino)methyl)benzoic acid

参考文献

1. Meenakshi Singh, et al. ACS Chem Biol. 2026 Jun 15. doi: 10.1021/acschembio.6c00240.

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