Auceliciclib (AU3-14, Ulecaciclib AU-314) | CDK4/6 inhibitor

Chemical Structure : AU3-14

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AU3-14 (Ulecaciclib, AU-314, Auceliciclib)

货号: PC-24989Not For Human Use, Lab Use Only.

Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM.

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生物&药学活性

Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM.
AU3-14 displaysselectivity that was 3-4 orders of magnitude greater for CDK4/cyclin D1 compared to CDK1/cyclin B1, CDK2/cyclin A2, CDK7/Mat1/cyclin H and CDK9/cyclin T1.
AU3-14 exhibits potent anti-proliferative effect against GBM cells with GI50 of2.17 - 3.54 µM.
AU3-14 inhibits Rb phosphorylation and arrests the cell cycle at the G1/G0 phase in GBM cells.
AU3-14 induces caspase-independent apoptosis in GBM cells. AU3-14 demonstrates potent tumor growth delay in GBM xenograft model.

物理化学性质&存储条件

分子量	496.65
分子式	C25H33FN8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Cyclopentyl-5-(2-((5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-4-methylthiazol-2-amine

参考文献

1. Mekonnen LB, et al. Biomed Pharmacother. 2025 Jul 11;189:118340.

2. Tadesse S, et al. J Med Chem. 2017 Mar 9;60(5):1892-1915.

AU3-14 (Ulecaciclib, AU-314, Auceliciclib)

生物&药学活性

物理化学性质&存储条件

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AU3-14 (Ulecaciclib, AU-314, Auceliciclib)

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