ATR inhibitor PB01

Chemical Structure : ATR inhibitor PB01

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货号: PC-24601Not For Human Use, Lab Use Only.

PB01 is a novel benzothiazole derivative that inhibit the proliferation of NSCLC cells, suppresses radio-resistance by regulating ATR signaling.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PB01 is a novel benzothiazole derivative that inhibit the proliferation of NSCLC cells, suppresses radio-resistance by regulating ATR signaling.
PB01 induces apoptotic cell death in NSCLC cells
PB01 induces apoptotic cell death via ATR-p53-GADD45ɑ in NSCLC cells.
PB01 induces time-dependent phosphorylation of JNK but not p-ERK, p-p38, and p-Akt.
PB01 suppresses the EMT phenotype in NSCLC and radio-resistant NSCLC cells
A combination of PB01 and radiation induce ER stress and apoptotic cell death in radio-resistant NSCLC cells
PB01 induces reactive oxygen species, ER stress, Bax, cytochrome c expression, the ATR-p53-GADD45ɑ axis, and cleavage of caspase-3 and -9.

物理化学性质&存储条件

分子量	431.57
分子式	C21H25N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexanecarboxamide, N-[2-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]-6-benzothiazolyl]-4-methoxy-

参考文献

1. Tae Woo Kim, et al. Sci Rep. 2021 Jun 8;11(1):12093.