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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-ATI-2173
ATI-2173

Chemical Structure : ATI-2173

CAS No.: 1951476-79-1

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ATI-2173 (ATI 2173)

货号: PC-38561Not For Human Use, Lab Use Only.

ATI-2173 is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ATI-2173 is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity.
    ATI-2173 is converted to the active 5′-triphosphate in hepatocytes.
    ATI-2173 showed similar activity across HBV genotypes A, B, C, D, E, F, G, and H (EC50 of 212 nM to 718 nM) in HepG2 assays.
    ATI-2173 activity was decreased by viral polymerase mutations associated with entecavir, lamivudine, and adefovir resistance, but not capsid inhibitor resistance mutations.
    ATI-2173 demonstrated 82% hepatic extraction, no food effect, and greatly reduced peripheral exposure of clevudine compared with equimolar oral dosing of clevudine.

    物理化学性质&存储条件

    分子量 529.458
    分子式 C22H29FN3O9P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    isopropyl ((S)-(((2S,3S,5S)-4-fluoro-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

    参考文献

    1. Squires KE, et al. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20.

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