ATG4B activator 16a

Chemical Structure : ATG4B activator 16a

加入收藏

货号: PC-26066Not For Human Use, Lab Use Only.

ATG4B activator 16a is a selective, allosteric small-molecule activator ATG4B, directly bind to the ATG4B with SPR KD of 0.22 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ATG4B activator 16a is a selective, allosteric small-molecule activator ATG4B, directly bind to the ATG4B with SPR KD of 0.22 uM.
ATG4B activator 16a can effectively inhibit the proliferation and migration of TNBC cells by suppressing MMP-2 mediated extracellular matrix degradation and reversing the EMT process.
ATG4B activator 16a induces autophagy to inhibit proliferation and migration in TNBC cells.
ATG4B activator 16a (5-20 mg/kg) induces autophagy to inhibit tumor growth and migration in the MDA-MB-231 xenograft model.

物理化学性质&存储条件

分子量	436.91
分子式	C25H22ClFN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2-Chloro-4-fluorobenzyl)oxy)-3-methoxybenzyl)-1-(quinolin-8-yl)methanamine

参考文献

1. Jin W, et al. Eur J Med Chem. 2026 Feb 17;308:118686.