ASS1 inhibitor C-01

Chemical Structure : ASS1 inhibitor C-01

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货号: PC-25222Not For Human Use, Lab Use Only.

ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM.
C-01 occupied the orthosteric sites of ASS1 and formed five hydrogen bonds with Arg157, Lys176, Met181, and Arg272 of ASS1, respectively.
C-01 (100 μM) effectively suppressed the phosphorylation of STAT3 in IL-6-exposed NCM460 cells.
C-01 suppresses the upregulated protein level of COX-2, P-mTOR, P-STAT3 and P-S6 in DSS mice, induces downregulation of arginine levels in both colon tissue and blood.
C-01 significantly alleviates intestinal inflammation in ulcerative colitis (UC) mouse models.

物理化学性质&存储条件

分子量	460.55
分子式	C23H28N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(N-(4-ethoxyphenyl)-N-propylsulfamoyl)indolin-1-yl)-4-oxobutanoic acid

参考文献

1. Liu S, et al. Nat Commun. 2025 Jul 30;16(1):6983.