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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-JNK-AS601245
AS601245

Chemical Structure : AS601245

CAS No.: 345987-15-7

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AS601245 (AS-601245)

货号: PC-42785Not For Human Use, Lab Use Only.

AS601245 is a potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AS601245 is a potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.
AS601245 is less potent for c-Src, c-Raf, p38a kinases.
AS601245 exhibits in vitro and in vivo anti-inflammatory potential.

物理化学性质&存储条件

分子量 372.4462
分子式 C20H16N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

2-Benzothiazoleacetonitrile, -[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-

参考文献

1. Gaillard P, et al. J Med Chem. 2005 Jul 14;48(14):4596-607.

2. Carboni S, et al. J Pharmacol Exp Ther. 2004 Jul;310(1):25-32.

3. Carboni S, et al. Br J Pharmacol. 2008 Jan;153(1):157-63.

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