AS4040605

Chemical Structure : AS4040605

加入收藏

货号: PC-24540Not For Human Use, Lab Use Only.

AS4040605 is a novel retinoic acid receptor-α (RARα) inhibitor, suppresses IL2+IL33-induced IL-5 production in mouse type 2 innate lymphoid cells (ILC2s) with IC50 of 7.9 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AS4040605 is a novel retinoic acid receptor-α (RARα) inhibitor, suppresses IL2+IL33-induced IL-5 production in mouse type 2 innate lymphoid cells (ILC2s) with IC50 of 7.9 nM.
AS4040605 inhibited not only the increased production of IL-5 by RA stimulation but also the increased production of IL-5 by IL-2+IL-33 stimulation.
AS4040605 acts as an inverse agonist of RARα on ILC2s.

物理化学性质&存储条件

分子量	423.41
分子式	C20H18FN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-(5-(1-fluorocyclopropyl)-1-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,4-triazine-3,5(2H,4H)-dione

参考文献

1. Hara-Tsuchiya C, et al. Eur J Pharmacol. 2025 Apr 25;999:177682.

AS4040605

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AS4040605

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.