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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-AS3334366
AS3334366

Chemical Structure : AS3334366

CAS No.: 2241300-49-0

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AS3334366

货号: PC-24915Not For Human Use, Lab Use Only.

AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM.

物理化学性质&存储条件

分子量 415.50
分子式 C23H25N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(1-(1-(4-methoxyphenyl)piperidin-4-yl)-4-methyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine

参考文献

1. Wang L, et al. Mater Today Bio. 2023 Jan 20;19:100557.

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