AS2676293 | RANKL inhibitor | Probechem Biochemicals

Chemical Structure : AS2676293

加入收藏

AS2676293 (AS 2676293)

货号: PC-21026Not For Human Use, Lab Use Only.

AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
AS2676293 (0.3-3 mg/kg, oral) inhibited bone loss significantly in RANKL-induced osteopenic mice.
AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.
AS2676293 suppressed RANKL-mediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10, which is known not to trigger osteoclast activation.

物理化学性质&存储条件

分子量	378.33
分子式	C18H14F4N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluoro-2-(trifluoromethyl)benzyl)-5-methoxy-2-(pyridin-2-yl)pyrimidin-4-amine

参考文献

1. Junji Miyata, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5681-4.

2. Vagelis Rinotas, et al. Int J Mol Sci. 2023 Jul 10;24(14):11290.

3. Nakai Y, et al. Bone Res. 2019 Jan 3;7:1. doi: 10.1038/s41413-018-0036-5.

AS2676293 (AS 2676293)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AS2676293 (AS 2676293)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.