AS1411 | Nucleolin inhibitor | Probechem Biochemicals

Chemical Structure : AS1411

CAS No.: 301636-59-9

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AS1411 (AGRO100)

货号: PC-22760Not For Human Use, Lab Use Only.

AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin, inhibits cancer cell proliferation.

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2 mg	￥2180	In stock
5 mg	￥3580	In stock
10 mg	￥5780	In stock
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100 mg		Get quote

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生物&药学活性

AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin, inhibits cancer cell proliferation.
AS1411 decreases level of PRMT5 in the nucleus of DU145 human prostate cancer cells, but increases PRMT5 in the cytoplasm.
AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.
AS1411 inhibits IKK activity and reduces phosphorylation of IkappaBalpha in response to tumor necrosis factor-alpha stimulation.
AS1411 blocks both tumor necrosis factor-alpha-induced and constitutive NF-kappaB activity in human cancer cell lines derived from cervical, prostate, breast, and lung carcinomas.

物理化学性质&存储条件

分子量	8272.31
分子式	C260H322N103O163P25
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Girvan AC, et al. Mol Cancer Ther. 2006 Jul;5(7):1790-9.

2. Teng Y, et al. Cancer Res. 2007 Nov 1;67(21):10491-500.

AS1411 (AGRO100)

生物&药学活性

物理化学性质&存储条件

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AS1411 (AGRO100)

生物&药学活性

物理化学性质&存储条件

参考文献

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