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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-AS-136A
AS-136A

Chemical Structure : AS-136A

CAS No.: 949898-66-2

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AS-136A (AS-136a, AS136A)

货号: PC-26062Not For Human Use, Lab Use Only.

AS-136A is a potent, non nucleoside inhibitor of measles virus (MeV) virus RNA-dependent RNA polymerase (RdRp) activity with EC50 of 12 nM against live MeV (strain Alaska) in virus titer reduction assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AS-136A is a potent, non nucleoside inhibitor of measles virus (MeV) virus RNA-dependent RNA polymerase (RdRp) activity with EC50 of 12 nM against live MeV (strain Alaska) in virus titer reduction assays.

物理化学性质&存储条件

分子量 402.39
分子式 C16H17F3N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-methyl-N-(4-(pyrrolidin-1-ylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

参考文献

1. Yoon JJ, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3860-70.

2. Ndungu JM, et al. J Med Chem. 2012 May 10;55(9):4220-30.

3. Aiming Sun, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5199-203.

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