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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-FABP-ART26.12
ART26.12

Chemical Structure : ART26.12

CAS No.: 2766800-24-0

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ART26.12 (ART 26.12)

货号: PC-21691Not For Human Use, Lab Use Only.

ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.
ART26.12 is effective at treating and preventing oxaliplatin-induced neuropathy.
Coadministration of ART26.12 (10 and 25 mg/kg BID for 15 days) with oxaliplatin prevented thermal hyperalgesia, mitigated mechanical allodynia, and attenuated OXA-induced weight loss in oxaliplatin-induced peripheral neuropathy (OIPN) model.

物理化学性质&存储条件

分子量 472.54
分子式 C29H28O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(+)-3-Indan-2-yloxycarbonyl-2,4-bis(2-methoxyphenyl)cyclobutanecarboxylic acid

参考文献

1. W G Warren, et al. J Pain. 2024 Jan 15:S1526-5900(24)00345-6.

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