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首页-小分子抑制剂&激动剂-Others-Other Targets-ARN398
ARN398

Chemical Structure : ARN398

CAS No.: 1466566-33-5

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ARN398 (ARN-398)

货号: PC-25426Not For Human Use, Lab Use Only.

ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS).

物理化学性质&存储条件

分子量 307.27
分子式 C12H16F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-hexyl-2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidine-1(2H)-carboxamide

参考文献

1. Realini N, et al. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035.

2. Realini N, et al. J Biol Chem. 2016 Jan 29;291(5):2422-34.

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