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首页-小分子抑制剂&激动剂-Others-Small GTPase-ARN25062
ARN25062

Chemical Structure : ARN25062

CAS No.: 3036492-85-7

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ARN25062 (ARN-25062)

货号: PC-22522Not For Human Use, Lab Use Only.

ARN25062 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 4.6-9.3 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ARN25062 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 4.6-9.3 uM.
    ARN25062 (10 mg/kg) significantly inhibits tumor growth in the PDX model.

    物理化学性质&存储条件

    分子量 398.43
    分子式 C22H21F3N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-phenyl-2-(piperidin-4-yl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine

    参考文献

    1. Brindani N, et al. J Med Chem. 2023 Apr 27;66(8):5981-6001.

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