ARN24928 (ARN-24928)

Chemical Structure : ARN24928

加入收藏

货号: PC-22521Not For Human Use, Lab Use Only.

ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.
ARN24928 (10 mg/kg) significantly inhibits tumor growth in the PDX model.

物理化学性质&存储条件

分子量	374.49
分子式	C22H26N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N1-dimethyl-N3-(4-phenyl-6-(piperidin-4-yl)-1,3,5-triazin-2-yl)benzene-1,3-diamine

参考文献

1. Brindani N, et al. J Med Chem. 2023 Apr 27;66(8):5981-6001.