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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Na-K-Cl Cotransporter (NKCC)-ARN23746
ARN23746

Chemical Structure : ARN23746

CAS No.: 2497525-96-7

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ARN23746 (IAMA-6, ARN-23746, IAMA6)

货号: PC-72424Not For Human Use, Lab Use Only.

ARN23746 (IAMA-6) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ARN23746 (IAMA-6) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.
ARN23746 did not show significant NKCC2 inhibition and KCC2 inhibition at 10 uM.
ARN23746 selectively blocks NKCC1 in a human cell line and restore the physiological [Cl−]i in murine DS neurons in culture, has excellent solubility and metabolic stability, and displays no issues with off-target activity in vitro.
ARN23746 demonstrated in vivo efficacy in rescuing cognitive impairment in a DS mouse model and social deficits and repetitive behaviors in an autism mouse model.

物理化学性质&存储条件

分子量 410.452
分子式 C17H25F3N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(N,N-dimethylsulfamoyl)-4-((8,8,8-trifluorooctyl)amino)benzoic acid

参考文献

1. Savardi A, et al. Chem. 2020 Aug 6;6(8):2073-2096.

2. Borgogno M, et al. J Med Chem. 2021 Jul 22;64(14):10203-10229.

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