ARN14988 | Acid ceramidase inhibitor | Probechem Biochemicals

Chemical Structure : ARN14988

加入收藏

ARN14988 (ARN-14988)

货号: PC-25425Not For Human Use, Lab Use Only.

ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM.
ARN14988 (2-20 uM) induces elevations in the levels of ceramide (d18:1/16:0) and its precursor dihydroceramide (d18:0/16:0) in A375 cells.
ARN14988 has little or no effect on the intracellular levels of sphingomyelin (d18:1/16:0) and glucosylceramide (d18:1/16:0).
ARN14988 modestly affected melanoma cell viability with EC50 of 51.9 uM in A375 cells and 77.3 uM in G361 cells.
ARN14988 is a potent and effective inhibitor of intracellular AC activity, which displays chemosensitizing properties in proliferative, but not invasive, melanoma cells.
ARN14988 normalized ceramide levels and concomitantly sensitized proliferative melanoma cells to the cytotoxic actions of various anti-tumoral agents.

物理化学性质&存储条件

分子量	373.83
分子式	C16H24ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1(2H)-Pyrimidinecarboxylic acid, 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-, 2-methylpropyl ester

参考文献

1. Realini N, et al. J Biol Chem. 2016 Jan 29;291(5):2422-34.

ARN14988 (ARN-14988)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ARN14988 (ARN-14988)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.