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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-ARCher-142
ARCher-142

Chemical Structure : ARCher-142

CAS No.: 618856-59-0

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ARCher-142 (TNKS2 ARC4 inhibitor S8)

货号: PC-25988Not For Human Use, Lab Use Only.

ARCher-142 (S8/ARCher-142) is a specific TNKS2 ARC4 inhibitor that specifically targeting the ARC4 peptide binding domain, binds selectively to TNKS2 ARC4 with a potency of 8 uM, attenuates the WNT/β-catenin pathway in cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARCher-142 (S8/ARCher-142) is a specific TNKS2 ARC4 inhibitor that specifically targeting the ARC4 peptide binding domain, binds selectively to TNKS2 ARC4 with a potency of 8 uM, attenuates the WNT/β-catenin pathway in cells.

物理化学性质&存储条件

分子量 466.53
分子式 C26H30N2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-(diethylamino)propyl)-4-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1,5-dihydro-2H-pyrrol-2-one

参考文献

1. Bosetti C, et al. Structure. 2026 Jan 30:S0969-2126(25)00496-4.

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