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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-AR7
AR7

Chemical Structure : AR7

CAS No.: 80306-38-3

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AR7 (AR-7, RARα antagonist AR7)

货号: PC-42316Not For Human Use, Lab Use Only.

AR7 (AR-7, AR 7) is a specific retinoid derivative that functions as a potent antagonist of RARα activity, specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.

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50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AR7 (AR-7, AR 7) is a specific retinoid derivative that functions as a potent antagonist of RARα activity, specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
AR7 shows no significant agonist or antagonist activity on RXR.
AR7 activate CMA through RARα signaling and not by direct interaction with CMA components in lysosomes.

物理化学性质&存储条件

分子量 257.71488
分子式 C15H12ClNO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2H-1,4-Benzoxazine, 7-chloro-3-(4-methylphenyl)-

参考文献

1. Anguiano J, et al. Nat Chem Biol. 2013 Jun;9(6):374-82.

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